PhD candidate: Diana RAMIREZ WONG

Date and place of defence: September 9, 2014 - UPMC, Paris, France.

 

The project aims at building a force- or temperature-responsive biocatalytic surface based on functional bio-organic nanotubes grafted on a surface. Our aim is to mimick some biological cell functions, where chemical reactions are controlled by stress or temperature. The nanotubes will contain an enzyme whose accessibility is modulated by stress or temperature, which affect the permeability of the outer shell of the nanotubes (scheme below).

Associated with this practical target are exciting scientific issues related to the assembly of chains and biomacromolecules in the nanotubes, such as tube composition, chain dynamics, and supramolecular structure. The project will therefore include an important analytical component, where advanced techniques of NMR spectroscopy will be used to answer such questions on very challengingly-tiny samples.

The project involves the use of templates produced by a Belgian spin-off company which has recently received a Japanese prize for technological innovation, it4ip, a NMR-specialized laboratory from University Paris-6, and a polymer nanotechnology-specialized lab from University of Louvain in Louvain-la-Neuve.

Principal investigators are Christian Bonhomme (UPMC-LCMCP), Sophie Demoustier and Alain M. Jonas (both UCL-POLY).